The Physiology of Neuromusculoskeletal Tissue (A Review Article)

The aim of this work is to consider the anatomical, physiological and biochemical mechanisms of normal functional movement processes, specifically looking at the basal ganglia and its role in functional movement control. This work will be relating pathophysiological changes that may occur in the basal ganglia resulting in a movement disorder, specifically dystonia. This work will also be considering a treatment that is currently used to alleviate some of the clinical manifestations of this syndrome, namely deep brain stimulation (DBS). The objectives of this work are: to look at the physiology and biochemical mechanisms of normal functional movement processes and relate these to the basal ganglia, considering how this area regulates movement processes through neural pathways or projections; to consider the physiological and biochemical changes that DBS may have on movement disorders, specifically dystonia.